My Sent and Trash folders (vers. 68.4.2 (32-bit)) have been emptied -- why?
I started my Thunderbird, created and sent an email. I then looked in the Sent folder and found it was empty. I know that there was several thousand emails in this folder a few days ago. The Trash folder was also empty. Note, some new folders were created but not by me -- Sent (2) and sent-mail (these had very old emails in them from 2014). A Trash10 folder was also created that is also empty.
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I think you can probably look to your anti virus for all of your problems. We generally suggest you create an exclusion in them for the Thunderbird profile because they are so slow at what they do that they seriously affect how Thunderbird works, including to the point of causing new numbered folders to be created because it has the original locked up with it's scanning.
The only difference to this will probably be the sent items folder. This is usually a clue you are connected to a Microsoft mail server using IMAP protocol. Did you perhaps recently change to IMAP?