What is your anti-virus software?

Whatever comes with Windows - Windows Security, Windows Firewall, ....

Try to start Windows 10 in safe mode with networking enabled.

Does the problem go away?

Windows safe mode disables anti-virus software. This is a troubleshooting step, not a solution.

This phenomenon does not occur often enough to where I feel safe turning anti-virus off. Any other suggestions?

Hi, I am running into the same situation. TB is "Not Responding" quite often. Only after upgrading to (128.1.0esr). I am running the default Microsoft Defender for anti-virus software. I am not running any extensions. All email is hosted on Godaddy.

Thank you, JR

This phenomenon does not occur often enough to where I feel safe turning anti-virus off.

As stated, this is a temporary troubleshooting step.

Any other suggestions?

It is entirely up to you to follow suggestions or not. But if you don't, then I'm done here.

dominic2,

please start a new topic for your problem. https://support.mozilla.org/questions/new

Hello, I can, but just curious, why a new topic when I am having the same issue. Thank you

why a new topic when I am having the same issue.

https://support.mozilla.org/en-US/kb/mozilla-support-rules-guidelines#w_posting-support-requests

christ1,

dominic2's issues is EXACTLY the same issue I am having. It is not "seemingly" the same issue.

Do you have another suggestion besides turning off anti-virus? If not, just say so.

FYI this phenomenon has not occurred for me in the last 36 hours. Do you really think it is wise to turn off anti-virus for that long?

You first outright declined to run Windows in safe mode, and now you're saying you were running Windows in safe mode for more than 36 hours? You'd need to clarify what you were doing, and what the result was. As a reminder, nobody else than you can see what happens on your screen. And you were not asked to turn off your anti-virus software for longer periods of time.

I apologize for not responding promptly. Life was getting in the way.

I never ran in Windows safe mode. My comment about not seeing the phenomenon for 36 hours was when I was running in "regular" mode with anti-virus turned on.

Now for new news. When not using my computer, I put it in sleep mode, choosing to restart about once a week. I only see the phenomenon of Thunderbird not responding when I wake up my computer / when I exit sleep mode. That did not happen with earlier versions of Thunderbird. The not responding message seems to last less than a minute.