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I cannot open downloaded files. The "Open" & "Open Containing Folder" options are grayed out, as well as the "Open" option. I have removed Kaspersky to sure.

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jiggasmuv
jiggasmuv
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I cannot open downloaded files. The "Open" & "Open Containing Folder" options are grayed out. Cannot right-click on the files to open. File does not appear in the targeted folder. If "opened," the files provide an error message. Issue is primarily with MS Word.

I cannot open downloaded files. The "Open" & "Open Containing Folder" options are grayed out. Cannot right-click on the files to open. File does not appear in the targeted folder. If "opened," the files provide an error message. Issue is primarily with MS Word.

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cor-el
cor-el
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If "Open" and "Open Containing Folder" in the right-click context menu in the Download Manager window are grayed then that means that the file is no longer in the original download location.
It is possible that your anti-virus software is corrupting the downloaded files or otherwise interfering with downloading files by Firefox.
Try to disable the real-time (live) scanning of files in your anti-virus software temporarily to see if that makes downloading work.

See "Disable virus scanning in Firefox preferences - Windows"