Are you talking backup, or are you planning to execute from the cloud? To backup, just do it when TB is not running. And the process is to copy, not to move.

I need a TB profile backup in the cloud, without any execution. But iCloud doesn't work like Google Drive. iCloud maintains an up-to-date copy of all files placed in the Desktop folder, and ignores other files--so they want you to put all your "data" in Desktop. But because the TB profile is a hidden file in Library on a mac, you can't just move it into the Desktop folder. If I copy it into Desktop, then I have two profile copies on my harddrive, and it costs me an extra 50GB of disc space on my mac. Is there no other option?