Sometimes this will happen with a new update, I have seen it when the what's new tour show up. However if this has happened again after restarting Firefox please try these steps:

• How to fix preferences that won't save

In case you use "Clear history when Firefox closes" or otherwise clear history.

• do not clear the Browsing History

• Tools > Options > Privacy > Firefox will: "Use custom settings for history": [X] "Clear history when Firefox closes" > Settings
• https://support.mozilla.org/kb/remove-recent-browsing-search-and-download-history

• Clearing "Site Preferences" clears all exceptions for cookies, images, pop-up windows, software installation, passwords, and other website specific data.

Are the backups in the sessionstore-backups folder updated?

previous.js (cleanBackup: copy of sessionstore.js from previous session that was loaded successfully)
recovery.js (latest version of the sessionstore written during runtime)
recovery.bak (previous version of the sessionstore written during runtime)
upgrade.js-<build_id> (backup created during an upgrade of Firefox)

You can copy a file from the sessionstore-backups folder to the main profile and rename the file to sessionstore.js to replace the current file (make a backup copy of the current sessionstore.js).