I and a colleague have investigated this issue and have determined that it appears to be firefox related and not MS Office or IE. When in firefox I would have to copy a cell of data from Excel either through right click or Ctrl-C and paste into a web-based application through firefox. Right click paste or Ctrl-V did not work. The paste option was greyed out in both instances. In Excel I could use either option to copy and paste from one spreadsheet to another, can copy paste from excel to IE to the same web-based app and copy from IE back out to Excel. Additionally, I can copy from Firefox and paste back into Excel. This also is not machine specific...this has been tested on at least two other machines with the same results.