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sending emails with attachments

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When sending an email with an attachment I get the following error:

Sending of the message failed. Unable to open the temporary file C:\Users\Office\AppData\Local\Temp\nsmail-1.tmp. Check your 'Temporary Directory' setting.

Saving the email to drafts, restarting Thunderbird, retrieving email from drafts and it will successfully send. Any suggestions?

When sending an email with an attachment I get the following error: Sending of the message failed. Unable to open the temporary file C:\Users\Office\AppData\Local\Temp\nsmail-1.tmp. Check your 'Temporary Directory' setting. Saving the email to drafts, restarting Thunderbird, retrieving email from drafts and it will successfully send. Any suggestions?

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Does this happen every time you try sending such messages or is it intermittent? Also, which antivirus program are you using?