Please share where all the files are now, as it is unclear from your post which indicates they are somewhat scattered. If the full profile is on a separate drive, I believe we can activate it. Is it also on the C drive too? Please also be specific on the assistance you want. For example, are you trying to recover some local folders, or to move the profile to a separate drive?

There is one version of the profile with the local folders on in C:\Users\me\AppData\Roaming\Thunderbird\Profiles\pmoiqt21.default\ImapMail\imap.gmail-1.com\Mail\Local Folders, and another in E:\Thunderbird\Mail\Local Folders. Both have the same content as far as I am aware, but neither show up in thunderbird.

I would like to recover the local folders, preferably in E, to avoid any bloat on C. If that is not possible, then recovering the local files in C, and then moving them to E.

I may want to see screenshots of those folders to verify their content, but I will make an initial suggestion to see if it does what you want. click 'account setting' and scroll down left side to 'Local Folders' and click that. To the right, you will then see 'Local Directory' and a browse button. Click the browse button and then locate and select the folder on drive E. That may require restarting thunderbird. Let know results an we can go from there.

That seems to have worked. All the folders are accounted for. That being said, does this mean I can delete the local files on my C drive so that only the ones on my E drive remain?

Yes, you may. And if you also have a local folders in the imapmail\<accountname> folder, that can also be deleted.

Reminder: when doing backups, keep in mind that you are using two different drives. People sometimes forget that. :)

Everything worked out great, thank you so so much for your help!!

I enjoyed assisting you. :)